Portsmouth to Cherbourg was somewhat of a younger route in P&O's history out of Portsmouth. P&O acquiring the service during the takeover of Townsend Thoresen in 1987. Prior to the takeover however there had been a service connecting Portsmouth to Cherbourg since the late 1970's when Townsend Thoresen slowly moved their operations from Southampton down to Portsmouth.
Over the 18 years of P&O operation between Portsmouth and Cherbourg many vessels have served the route faithfully.
| Ships Operating | Dates |
| mv Pride of Cherbourg |
2002 to 2005 |
| mv Pride of Bilbao |
Friday Night Caberet Cruises 1993 to 2004 |
| hsc Cherbourg Express |
2000 to 2004 |
| hsc Superstar Express | 1998 to 2000 |
| mv Pride of Cherbourg | 1994 to 2002 |
| mv Pride of Hampshire | 1994 to 2002 |
| mv Pride of Cherbourg | 1989 to 1994 |
| mv Pride of Winchester | 1989 to 1994 |
| mv Viking Voyager | 1987 to 1989 |
| mv Viking Viscount | 1987 to 1989 |